Space Empires V!
It's a large-scale turn-based space colonization game. It's nifty and customizable, and I have an extractable for it that's smaller than a Starcraft ISO.
This is the sort of game we could play for weeks or months at a time, which is cool, and it wouldn't necessarily replace other, faster games like Starcraft.
EDIT:
From the site!
* 24bit 3D rendered graphics.
* Support for 1024x768 and greater resolutions.
* Turn-Based and Simultaneous Turn Game Play.
* Detailed Real-Time Tactical Space Combat (and a combat simulator to test your designs!).
* Detailed Real-Time Tactical Ground Combat (and a combat simulator to test your designs!).
* Ability to completely design and customize all of your vehicles.
* Detailed Empire management: Research, Intelligence, Politics, Construction Queues, Vehicle Design, and more.
* Detailed game setup: Victory Conditions, Restricted Technologies, Galaxy Layout, Player Configuraton, and more.
* Large Galaxy: 100 solar systems with 15 planets each.
* Randomly generated map for every game (or load an existing map).
* Discover: Black Holes, Nebulae, Binary Stars, Trinary Stars, Asteroid Belts, Gas Giants, Cosmic Storms, and more!
* Huge Technology Tree: Over 6000 tech levels, 500+ components and facilities.
* Detailed Race Creation: Unique ship models, race picture, racial traits, technology, history, and more.
* Completely customizable game graphics: Create your own planets, stars, vehicles,etc.
* Completely customizable data files: All game information is in easily editable text files. Create your own Components, Facilities, Vehicle Sizes, etc.
* Completely customizable AI players: Create your own AI players with unique traits, styles, and speech (even script the AI yourself!)
* Game comes with 14 unique races to play or customize (or just create your own!)
* Right-click menus return!
* Advanced Political features: Protectorates, Subjugated empires, trade game items, claim territories, form alliances, and more.
* Random Events: Rebellions, earthquakes, supernovas, industrial accidents, cosmic storms, and the occasional plague!